HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-((2-(Diethylamino)ethyl)carbamoyl)phenyl)boronic acid hydrochloride → 4-[8-(2-chloro-3,6-difluorobenzyl)-5,6,7,8-tetrahydropyrazino[2,3-b]pyrazin-2-yl]-N-[2-(diethylamino)ethyl]benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-((2-(Diethylamino)ethyl)carbamoyl)phenyl)boronic acid hydrochloride | HCID 44119574 | — |
| Reactant | 7-Bromo-1-(2-chloro-3,6-difluorobenzyl)-1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine | HCID 86659422 | — |
| Product | 4-[8-(2-chloro-3,6-difluorobenzyl)-5,6,7,8-tetrahydropyrazino[2,3-b]pyrazin-2-yl]-N-[2-(diethylamino)ethyl]benzamide | HCID 67008145 | — |
Reaction Steps
The entitled compound was prepared from 7-bromo-1-(2-chloro-3,6-difluorobenzyl)-1,2,3,4-tetrahydropyrazino[2,3-b]pyrazine and 4-{[2-(Diethylamino)ethyl]carbamoyl}benzeneboronic acid hydrochloride using Suzuki coupling conditions as described in Scheme 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846664B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-1a5138b3c8d74f579440c419f67b8656 |
| Source note | uspto-grants-2014_09 |