N-tert-butyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-sulfonamide → 5-{3-[4-(5-Chloro-thiophen-2-yl)-6-trifluoromethyl-pyrimidin-2-yl]-phenyl}-thiophene-2-sulfonic acid tert-butylamide

HRID 805568Notes

Reaction equation

HRID 805568 reaction equation
[Br:1][c:2]1[cH:3][c:4](-[c:8]2[n:9][c:10]([C:20]([F:21])([F:22])[F:23])[cH:11][c:12](-[c:14]3[s:15][c:16]([Cl:19])[cH:17][cH:18]3)[n:13]2)[cH:5][cH:6][cH:7]1.[C:24]([CH3:25])([CH3:26])([CH3:27])[NH:28][S:29](=[O:30])(=[O:31])[c:32]1[s:33][c:34]([B:37]2[O:38][C:39]([CH3:40])([CH3:41])[C:42]([CH3:43])([CH3:44])[O:45]2)[cH:35][cH:36]1>>[c:2]1(-[c:34]2[s:33][c:32]([S:29]([NH:28][C:24]([CH3:25])([CH3:26])[CH3:27])(=[O:30])=[O:31])[cH:36][cH:35]2)[cH:3][c:4](-[c:8]2[n:9][c:10]([C:20]([F:21])([F:22])[F:23])[cH:11][c:12](-[c:14]3[s:15][c:16]([Cl:19])[cH:17][cH:18]3)[n:13]2)[cH:5][cH:6][cH:7]1

Participants

3

Reactant 2

HCID 57468817N-tert-butyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-sulfonamideHCID 673946642-(3-Bromo-phenyl)-4-(5-chloro-thiophen-2-yl)-6-trifluoromethyl-pyrimidine

Product 1

HCID 673933055-{3-[4-(5-Chloro-thiophen-2-yl)-6-trifluoromethyl-pyrimidin-2-yl]-phenyl}-thiophene-2-sulfonic acid tert-butylamide

Sources & evidence

ORD record
ord-2b67cfa939f142a1a0da93479c33f635
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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