N-(2-Morpholinoethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine → HCID 67007874, compound

HRID 80561Notes

Reaction equation

HRID 80561 reaction equation
Br[C:2]1[CH:21]=[N:20][C:5]2[NH:6][CH2:7][CH2:8][N:9]([CH2:10][C:11]3[C:16]([F:17])=[CH:15][CH:14]=[C:13]([F:18])[C:12]=3[Cl:19])[C:4]=2[C:3]=1[CH3:22].[O:23]1[CH2:28][CH2:27][N:26]([CH2:29][CH2:30][NH:31][C:32]2[CH:37]=[CH:36][C:35](B3OC(C)(C)C(C)(C)O3)=[CH:34][N:33]=2)[CH2:25][CH2:24]1>>[Cl:19][C:12]1[C:13]([F:18])=[CH:14][CH:15]=[C:16]([F:17])[C:11]=1[CH2:10][N:9]1[CH2:8][CH2:7][NH:6][C:5]2[N:20]=[CH:21][C:2]([C:35]3[CH:36]=[CH:37][C:32]([NH:31][CH2:30][CH2:29][N:26]4[CH2:27][CH2:28][O:23][CH2:24][CH2:25]4)=[N:33][CH:34]=3)=[C:3]([CH3:22])[C:4]1=2

Participants

3

Reactant 2

HCID 17750274N-(2-Morpholinoethyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amineHCID 670070637-Bromo-1-(2-chloro-3,6-difluorobenzyl)-8-methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine

Product 1

HCID 67007874HCID 67007874, compound

Procedure

The entitled compound can be prepared from 7-bromo-1-(2-chloro-3,6-difluorobenzyl)-8-methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine and 2-(2-morpholinoethylamino)pyridine-5-boronic acid pinacol ester as described in example 25.

Sources & evidence

ORD record
ord-17aa734294664977b0171d7a1413c02d
Source dataset
uspto-grants-2014_09
Patent number
US08846664B2

Reaction notes

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