HRID80562

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN1CCN(CCOc2ccc(B3OC(C)(C)C(C)(C)O3)cc2)CC1

HCID53440265

1-Methyl-4-{2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethyl}piperazine

C19H31BN2O3

结构：Cc1c(Br)cnc2c1N(Cc1c(F)ccc(F)c1Cl)CCN2

HCID67007063

未命名化合物

PRODUCTS

生成物

结构：Cc1c(-c2ccc(OCCN3CCN(C)CC3)cc2)cnc2c1N(Cc1c(F)ccc(F)c1Cl)CCN2

HCID67008236

未命名化合物

PROCEDURE

实验过程

The entitled compound can be prepared from 7-bromo-1-(2-chloro-3,6-difluorobenzyl)-8-methyl-1,2,3,4-tetrahydropyrido[2,3-b]pyrazine and 1-methyl-4-{2-[4-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-phenoxy]-ethyl}-piperazine as described in example 25.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-35c3beb801884300aec7ff642e481e9a
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08846664B2
来源说明: uspto-grants-2014_09

反应 SMILES

Br[C:2]1[CH:21]=[N:20][C:5]2[NH:6][CH2:7][CH2:8][N:9]([CH2:10][C:11]3[C:16]([F:17])=[CH:15][CH:14]=[C:13]([F:18])[C:12]=3[Cl:19])[C:4]=2[C:3]=1[CH3:22].[CH3:23][N:24]1[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][O:32][C:33]2[CH:38]=[CH:37][C:36](B3OC(C)(C)C(C)(C)O3)=[CH:35][CH:34]=2)[CH2:26][CH2:25]1>>[Cl:19][C:12]1[C:13]([F:18])=[CH:14][CH:15]=[C:16]([F:17])[C:11]=1[CH2:10][N:9]1[CH2:8][CH2:7][NH:6][C:5]2[N:20]=[CH:21][C:2]([C:36]3[CH:37]=[CH:38][C:33]([O:32][CH2:31][CH2:30][N:27]4[CH2:26][CH2:25][N:24]([CH3:23])[CH2:29][CH2:28]4)=[CH:34][CH:35]=3)=[C:3]([CH3:22])[C:4]1=2