Benzylsulfamic acid [5-(2-chloro-5-methoxy-phenoxy)-6-(2-hydroxy-ethoxy) pyrimidin-4-yl]-amide → Benzylsulfamic acid [6-[2-(5-methylsulfanyl-pyrimidin-2-yloxy)ethoxy]-5-(2-chloro-5-methoxy-phenoxy)pyrimidin-4-yl]-amide

HRID 805694Notes

Reaction equation

HRID 805694 reaction equation
[CH3:33][S:34][c:35]1[cH:36][n:37][c:38]([Cl:41])[n:39][cH:40]1.[Cl:1][c:2]1[c:3]([O:4][c:5]2[c:6]([NH:15][S:16]([NH:17][CH2:18][c:19]3[cH:20][cH:21][cH:22][cH:23][cH:24]3)(=[O:25])=[O:26])[n:7][cH:8][n:9][c:10]2[O:11][CH2:12][CH2:13][OH:14])[cH:27][c:28]([O:31][CH3:32])[cH:29][cH:30]1>>[Cl:1][c:2]1[c:3]([O:4][c:5]2[c:6]([NH:15][S:16]([NH:17][CH2:18][c:19]3[cH:20][cH:21][cH:22][cH:23][cH:24]3)(=[O:25])=[O:26])[n:7][cH:8][n:9][c:10]2[O:11][CH2:12][CH2:13][O:14][c:38]2[n:37][cH:36][c:35]([S:34][CH3:33])[cH:40][n:39]2)[cH:27][c:28]([O:31][CH3:32])[cH:29][cH:30]1

Participants

3

Reactant 2

HCID 21041229Benzylsulfamic acid [5-(2-chloro-5-methoxy-phenoxy)-6-(2-hydroxy-ethoxy) pyrimidin-4-yl]-amideHCID 219795322-Chloro-5-(methylthio)pyrimidine

Product 1

HCID 21979560Benzylsulfamic acid [6-[2-(5-methylsulfanyl-pyrimidin-2-yloxy)ethoxy]-5-(2-chloro-5-methoxy-phenoxy)pyrimidin-4-yl]-amide

Sources & evidence

ORD record
ord-1c6ec9250de74f1fabfd2068021b41a8
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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