{4-[2-(1H-Imidazol-1-yl)ethoxy]phenyl}boronic acid → HCID 46202073, compound

HRID 80570Notes

Reaction equation

HRID 80570 reaction equation
Br[C:2]1[CH:3]=[N:4][C:5]2[NH:11][CH2:10][CH2:9][CH2:8][N:7]([CH2:12][C:13]3[C:18]([F:19])=[CH:17][CH:16]=[C:15]([F:20])[C:14]=3[Cl:21])[C:6]=2[N:22]=1.[N:23]1([CH2:28][CH2:29][O:30][C:31]2[CH:36]=[CH:35][C:34](B(O)O)=[CH:33][CH:32]=2)[CH:27]=[CH:26][N:25]=[CH:24]1>>[Cl:21][C:14]1[C:15]([F:20])=[CH:16][CH:17]=[C:18]([F:19])[C:13]=1[CH2:12][N:7]1[CH2:8][CH2:9][CH2:10][NH:11][C:5]2[N:4]=[CH:3][C:2]([C:34]3[CH:35]=[CH:36][C:31]([O:30][CH2:29][CH2:28][N:23]4[CH:27]=[CH:26][N:25]=[CH:24]4)=[CH:32][CH:33]=3)=[N:22][C:6]1=2

Participants

3

Reactant 2

HCID 44118566{4-[2-(1H-Imidazol-1-yl)ethoxy]phenyl}boronic acidHCID 866594302-Bromo-9-(2-chloro-3,6-difluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrazino[2,3-b][1,4]diazepine

Product 1

HCID 46202073HCID 46202073, compound

Procedure

The entitled compound can be prepared from 2-Bromo-9-(2-chloro-3,6-difluorobenzyl)-6,7,8,9-tetrahydro-5H-pyrazino[2,3-b][1,4]diazepine and 4-(2-(1H-imidazol-1-yl)ethoxy)phenyl boronic acid as described in example 1 or 30.

Sources & evidence

ORD record
ord-ad12fac97cac4c28a424849e1c339f7a
Source dataset
uspto-grants-2014_09
Patent number
US08846664B2

Reaction notes

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