Acetonitrile → (3RS,4SR)-3-(3,4-Dichloro-phenyl)-4-[(RS)-1-(4-trifluoromethyl-phenoxy)-ethyl]-pyrrolidine
Reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH:10]([c:26]2[cH:27][c:28]([Cl:33])[c:29]([Cl:32])[cH:30][cH:31]2)[CH:11]([CH:13]([CH3:14])[O:15][c:16]2[cH:17][cH:18][c:19]([C:22]([F:23])([F:24])[F:25])[cH:20][cH:21]2)[CH2:12]1.[CH3:43][C:44]#[N:45].[Cl:34][C:35]([O:36][CH2:37][C:38]([Cl:39])([Cl:40])[Cl:41])=[O:42]>>[NH:8]1[CH2:9][CH:10]([c:26]2[cH:27][c:28]([Cl:33])[c:29]([Cl:32])[cH:30][cH:31]2)[CH:11]([CH:13]([CH3:14])[O:15][c:16]2[cH:17][cH:18][c:19]([C:22]([F:23])([F:24])[F:25])[cH:20][cH:21]2)[CH2:12]1Participants
4
Sources & evidence
- ORD record
- ord-d35149eecaed48c69a6da482a4f9bef1
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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