化工社化工社 化学情報印刷レポート · 研究参考用
Pyridine → 3,5-Dimethyl-1-(3-nitrophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Ethyl 2-acetylacetoacetate | HCID 79063 | — |
| 反応物 | 3-Nitrophenylhydrazinium(1+) chloride | HCID 5464285 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3,5-Dimethyl-1-(3-nitrophenyl)-1H-pyrazole-4-carboxylic acid ethyl ester | HCID 656969 | — |
反応手順
Similar to Example 1, m-nitrophenylhydrazine hydrochloride (10 mmol, 1.9 g) and 2-acetyl-3-oxo-butyric acid ethyl ester (10 mmol, 1.7 g) were mixed in a 50% solution of pyridine in ethanol. A precipitate was formed in the reaction medium, and was collected by filtration. Analysis confirmed synthesis of the named product, m.p., 107.7° C.–109.2° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07087634B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-429914abd99c47c1b147ebf79f741665 |
| 出典メモ | uspto-grants-2006_08 |