Dimethylamine → 4-(3-Chloro-2-fluoroanilino)-6-[-1-(N,N-dimethylaminoacetyl)piperidin-3-yloxy]-7-methoxyquinazoline
Reaction equation
[CH3:33][NH:34][CH3:35].[CH3:36][CH2:37][OH:38].[Cl:1][CH2:2][C:3](=[O:4])[N:5]1[CH2:6][CH:7]([O:11][c:12]2[cH:13][c:14]3[c:15]([NH:24][c:25]4[c:26]([F:32])[c:27]([Cl:31])[cH:28][cH:29][cH:30]4)[n:16][cH:17][n:18][c:19]3[cH:20][c:21]2[O:22][CH3:23])[CH2:8][CH2:9][CH2:10]1>>[CH2:2]([C:3](=[O:4])[N:5]1[CH2:6][CH:7]([O:11][c:12]2[cH:13][c:14]3[c:15]([NH:24][c:25]4[c:26]([F:32])[c:27]([Cl:31])[cH:28][cH:29][cH:30]4)[n:16][cH:17][n:18][c:19]3[cH:20][c:21]2[O:22][CH3:23])[CH2:8][CH2:9][CH2:10]1)[N:34]([CH3:33])[CH3:35]Participants
4
Sources & evidence
- ORD record
- ord-85963539beae450397bdb54924529cdc
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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