2-(Methylsulfonyl)ethanamine → 2,6-Difluoro-N-{2-fluoro-3-[5-(2-{[2-(methylsulfonyl)ethyl]amino}-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

HRID 805991Notes

Reaction equation

HRID 805991 reaction equation
[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:19]3[c:20]([F:37])[c:21]([NH:25][S:26](=[O:27])(=[O:28])[c:29]4[c:30]([F:36])[cH:31][cH:32][cH:33][c:34]4[F:35])[cH:22][cH:23][cH:24]3)[n:10][c:11]([N:13]3[CH2:14][CH2:15][O:16][CH2:17][CH2:18]3)[s:12]2)[n:7]1.[NH2:38][CH2:39][CH2:40][S:41](=[O:42])(=[O:43])[CH3:44]>>[c:2]1([NH:38][CH2:39][CH2:40][S:41](=[O:42])(=[O:43])[CH3:44])[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:19]3[c:20]([F:37])[c:21]([NH:25][S:26](=[O:27])(=[O:28])[c:29]4[c:30]([F:36])[cH:31][cH:32][cH:33][c:34]4[F:35])[cH:22][cH:23][cH:24]3)[n:10][c:11]([N:13]3[CH2:14][CH2:15][O:16][CH2:17][CH2:18]3)[s:12]2)[n:7]1

Participants

3

Reactant 2

HCID 43405612-(Methylsulfonyl)ethanamineHCID 57989866N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

Product 1

HCID 579896962,6-Difluoro-N-{2-fluoro-3-[5-(2-{[2-(methylsulfonyl)ethyl]amino}-4-pyrimidinyl)-2-(4-morpholinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

Sources & evidence

ORD record
ord-02252b20c46e4393af6ca8d67ab5029b
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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