5-Chloro-2-thiophenecarboxylic acid → 3-{2-[(5-Chloro-thiophene-2-carbonyl)-amino]-ethanesulfonylamino}-azetidine-1-carboxylic acid tert-butyl ester

HRID 806013Notes

Reaction equation

HRID 806013 reaction equation
[C:10]([CH3:11])([CH3:12])([CH3:13])[O:14][C:15](=[O:16])[N:17]1[CH2:18][CH:19]([NH:21][S:22](=[O:23])(=[O:24])[CH2:25][CH2:26][NH2:27])[CH2:20]1.[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:7](=[O:8])[OH:9])[s:6]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:7](=[O:9])[NH:27][CH2:26][CH2:25][S:22]([NH:21][CH:19]2[CH2:18][N:17]([C:15]([O:14][C:10]([CH3:11])([CH3:12])[CH3:13])=[O:16])[CH2:20]2)(=[O:23])=[O:24])[s:6]1

Participants

3

Reactant 2

HCID 950485-Chloro-2-thiophenecarboxylic acidHCID 666246733-(2-Amino-ethanesulfonylamino)-azetidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 666248523-{2-[(5-Chloro-thiophene-2-carbonyl)-amino]-ethanesulfonylamino}-azetidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-d8a38abbad1549a2aedfe24bb370e269
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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