Cyclopropylamine → 5-bromo-N-cyclopropylpyrimidin-2-amine
Reaction equation
[Br:1][C:2]1[CH:3]=[N:4][C:5](Cl)=[N:6][CH:7]=1.[CH:9]1([NH2:12])[CH2:11][CH2:10]1>C(O)C>[Br:1][C:2]1[CH:3]=[N:4][C:5]([NH:12][CH:9]2[CH2:11][CH2:10]2)=[N:6][CH:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
In a pressure tube with one end sealed, add 193 mg 5-bromo-2-chloropyrimidine (1.0 mmol) and 285 mg cyclopropylamine (5.0 mmol) in 3.0 mL ethanol, and the mixture is heated to 80° C. and stirred for 3 h. The reaction mixture was cooled to room temperature, and 203 mg solid product was collected by filtration for direct use yield: 95%).
Workup
- customIn a pressure tube with one end sealed
- temperatureThe reaction mixture was cooled to room temperature
- filtration203 mg solid product was collected by filtration for direct use yield: 95%)
Sources & evidence
- ORD record
- ord-06f8f28b92324da09086f457db695e4e
- Source dataset
- uspto-grants-2014_09
- Patent number
- US08846671B2
Reaction notes
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