反应详情

A mixture of 1 g of (S)-2-chloro-8-trifluoromethyl-6,7,8,9-tetrahydro-pyrimido[1,2-a]pyrimidin-4-one and of 15 ml of morpholine is heated at 80° C. After one and a half hours of heating and after verification by LC/MS, the reaction is complete. After cooling, the reaction mixture is concentrated under reduced pressure. 10 ml of cold water and 100 ml of ethyl acetate are added to the residue obtained. The resulting organic phase is separated and then dried over magnesium sulphate, filtered, and concentrated under reduced pressure so as to give 1.2 g of (S)-2-morpholin-4-yl-8-trifluoromethyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one, the characteristics of which are the following:

1. temperatureAfter one and a half hours of heating
2. temperatureAfter cooling
3. concentrationthe reaction mixture is concentrated under reduced pressure
4. addition10 ml of cold water and 100 ml of ethyl acetate are added to the residue
5. customobtained
6. customThe resulting organic phase is separated
7. dry with materialdried over magnesium sulphate
8. filtrationfiltered
9. concentrationconcentrated under reduced pressure so as