HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluorobenzoyl chloride → HCID 49854297, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluorobenzoyl chloride | HCID 9808 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | (S)-8-(Morpholin-4-yl)-2-(trifluoromethyl)-1,2,3,4-tetrahydropyrimido[1,2-a]pyrimidin-6-one | HCID 136238743 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 49854297 | HCID 49854297 | — |
Reaction Steps
The product is prepared according to the procedure described in Example 18, using 300 mg of (8S)-2-morpholin-4-yl-8-trifluoromethyl-6,7,8,9-tetrahydropyrimido[1,2-a]pyrimidin-4-one (Example 1e), 47 mg of sodium hydride and 156 mg of 2-fluorobenzoyl chloride in 5 ml of tetrahydrofuran. After purification by silica chromatography (eluent: CH2Cl2/MeOH 98/02), 35 mg of (8S)-9-[(2-fluorophenyl)carbonyl]-2-(morpholin-4-yl)-8-(trifluoro-methyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one are obtained in the form of a white foam, the characteristics of which are the following:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846670B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-3040e79ef21a4400bbe72f3ce6f8366e |
| Source note | uspto-grants-2014_09 |