反应详情

温度

20 °C

767 mg of thionyl chloride are added to a solution of 1 g of commercial 1-(2-fluorophenyl)ethanol in 20 ml of chloroform. After stirring overnight at a temperature in the region of 20° C., the reaction mixture is washed with a saturated aqueous solution of sodium bicarbonate and then dried over anhydrous magnesium sulphate, filtered and concentrated to dryness under reduced pressure. 780 mg of 1-(1-chloroethyl)-2-fluorobenzene are thus obtained, said product being used as it is in the next stage.

1. washthe reaction mixture is washed with a saturated aqueous solution of sodium bicarbonate
2. dry with materialdried over anhydrous magnesium sulphate
3. filtrationfiltered
4. concentrationconcentrated to dryness under reduced pressure