2-(4-(Methylcarbamoyl)piperidin-1-yl)acetic acid → 1-(2-((2-((2,4-dichloro-3-(((2-methoxy-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-4-yl)oxy)methyl)phenyl)(methyl)amino)-2-oxoethyl)amino)-2-oxoethyl)-N-methylpiperidine-4-carboxamide
Reaction equation
[CH3:1][NH:2][C:3](=[O:4])[CH:5]1[CH2:6][CH2:7][N:8]([CH2:11][C:12](=[O:13])[OH:14])[CH2:9][CH2:10]1.[Cl:49][c:50]1[c:51]([CH2:52][O:53][c:54]2[c:55]3[n:56][c:57]([O:58][CH3:59])[n:60]([CH2:61][c:62]4[cH:63][cH:64][cH:65][cH:66][n:67]4)[c:68]3[cH:69][cH:70][cH:71]2)[c:72]([Cl:73])[cH:74][cH:75][c:76]1[N:77]([CH3:78])[C:79](=[O:80])[CH2:81][NH:82][C:83](=[O:84])[CH2:85][CH2:86][c:87]1[cH:88][cH:89][c:90]([C:91]([NH:92][CH2:93][CH2:94][O:95][CH3:96])=[O:97])[cH:98][cH:99]1.[NH2:15][CH2:16][C:17](=[O:18])[N:19]([CH3:20])[c:21]1[c:22]([Cl:48])[c:23]([CH2:28][O:29][c:30]2[cH:31][cH:32][cH:33][c:34]3[n:35]([CH2:41][c:42]4[n:43][cH:44][cH:45][cH:46][cH:47]4)[c:36]([O:39][CH3:40])[n:37][c:38]23)[c:24]([Cl:27])[cH:25][cH:26]1>>[CH3:1][NH:2][C:3](=[O:4])[CH:5]1[CH2:6][CH2:7][N:8]([CH2:11][C:12](=[O:14])[NH:15][CH2:16][C:17](=[O:18])[N:19]([CH3:20])[c:21]2[c:22]([Cl:48])[c:23]([CH2:28][O:29][c:30]3[cH:31][cH:32][cH:33][c:34]4[n:35]([CH2:41][c:42]5[n:43][cH:44][cH:45][cH:46][cH:47]5)[c:36]([O:39][CH3:40])[n:37][c:38]34)[c:24]([Cl:27])[cH:25][cH:26]2)[CH2:9][CH2:10]1Participants
4
Reactant 3
HCID 544332582-(4-(Methylcarbamoyl)piperidin-1-yl)acetic acid
HCID 667603852-amino-N-(2,4-dichloro-3-(((2-methoxy-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-4-yl)oxy)methyl)phenyl)-N-methylacetamide
HCID 667609784-(3-((2-((2,4-dichloro-3-(((2-methoxy-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-4-yl)oxy)methyl)phenyl)(methyl)amino)-2-oxoethyl)amino)-3-oxopropyl)-N-(2-methoxyethyl)benzamideProduct 1
Sources & evidence
- ORD record
- ord-6896a83c111446a6a4a9afbb2e5ae5c1
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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