Acetate → 1-[6-Chloro-1-(3,5-difluoro-phenyl)-1H-indol-3-yl]-2,2,2-trifluoro-ethanone

HRID 806412Notes

Reaction equation

HRID 806412 reaction equation
[C:37]([O-:38])(=[O:39])[CH3:40].[C:42]([O-:43])(=[O:44])[CH3:45].[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([C:11]([C:12]([F:13])([F:14])[F:15])=[O:16])[cH:7][nH:8][c:9]2[cH:10]1.[Cl:34][CH2:35][Cl:36].[Cu+2:41].[F:17][c:18]1[cH:19][c:20]([B:25]([OH:26])[OH:27])[cH:21][c:22]([F:24])[cH:23]1.[cH:28]1[cH:29][cH:30][n:31][cH:32][cH:33]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([C:11]([C:12]([F:13])([F:14])[F:15])=[O:16])[cH:7][n:8](-[c:20]3[cH:19][c:18]([F:17])[cH:23][c:22]([F:24])[cH:21]3)[c:9]2[cH:10]1

Participants

7

Reactant 6

HCID 175Acetate2×HCID 1049PyridineHCID 6344DichloromethaneHCID 27099Cupric cationHCID 2734338(3,5-Difluorophenyl)boronic acidHCID 224972521-(6-Chloro-3-indolyl)-2,2,2-trifluoroethanone

Product 1

HCID 866101631-[6-Chloro-1-(3,5-difluoro-phenyl)-1H-indol-3-yl]-2,2,2-trifluoro-ethanone

Sources & evidence

ORD record
ord-f28e12a6af834471ad6f65ee04c82df9
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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