Isopropyl chloroformate → HCID 25174267, compound

HRID 80651Notes

Reaction equation

[F:1][C:2]1[CH:20]=[C:19]([S:21]([CH3:24])(=[O:23])=[O:22])[CH:18]=[CH:17][C:3]=1[O:4][CH2:5][C:6]1[CH:10]=[N:9][N:8]([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[N:7]=1.Cl[C:26]([O:28][CH:29]([CH3:31])[CH3:30])=[O:27]>>[F:1][C:2]1[CH:20]=[C:19]([S:21]([CH3:24])(=[O:23])=[O:22])[CH:18]=[CH:17][C:3]=1[O:4][CH2:5][C:6]1[CH:10]=[N:9][N:8]([CH:11]2[CH2:12][CH2:13][N:14]([C:26]([O:28][CH:29]([CH3:31])[CH3:30])=[O:27])[CH2:15][CH2:16]2)[N:7]=1

Participants

Reactant 2

HCID 7917Isopropyl chloroformate

HCID 57708381HCID 57708381, compound2×

Product 1

HCID 25174267HCID 25174267, compound

Procedure

The title compound was synthesized using 4-[4-(2-Fluoro-4-methanesulfonyl-phenoxymethyl)-[1,2,3]triazol-2-yl]-piperidine (Intermediate 7) and isopropyl chloroformate in a manner similar to that described in Example 35. 1H NMR (CDCl3): δ 7.66 (3H, m), 7.27 (1H, m), 5.30 (2H, s), 4.94 (1H, m), 4.63 (1H, m), 4.20 (2H, m), 3.04 (3H, s), 2.19 (2H, m), 2.17 (2H, m), 1.25 (6H, d).

Sources & evidence

ORD record: ord-15ff8d7f149e4eeea2c827d470fa38c5
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08846675B2

Reaction notes

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