5-((2-(piperidin-4-yl)-2H-1,2,3-triazol-4-yl)methoxy)-2-(1H-tetrazol-1-yl)pyridine hydrochloride → HCID 178527375, compound

HRID 80654Notes

Reaction equation

HRID 80654 reaction equation
Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([N:8]2[N:12]=[C:11]([CH2:13][O:14][C:15]3[CH:16]=[CH:17][C:18]([N:21]4[CH:25]=[N:24][N:23]=[N:22]4)=[N:19][CH:20]=3)[CH:10]=[N:9]2)[CH2:4][CH2:3]1.[NH:26]1[CH:30]=[C:29]([S:31](Cl)(=[O:33])=[O:32])[N:28]=[CH:27]1>>[NH:26]1[CH:30]=[C:29]([S:31]([N:2]2[CH2:3][CH2:4][CH:5]([N:8]3[N:12]=[C:11]([CH2:13][O:14][C:15]4[CH:16]=[CH:17][C:18]([N:21]5[CH:25]=[N:24][N:23]=[N:22]5)=[N:19][CH:20]=4)[CH:10]=[N:9]3)[CH2:6][CH2:7]2)(=[O:33])=[O:32])[N:28]=[CH:27]1

Participants

3

Reactant 2

HCID 687466245-((2-(piperidin-4-yl)-2H-1,2,3-triazol-4-yl)methoxy)-2-(1H-tetrazol-1-yl)pyridine hydrochlorideHCID 178527435HCID 178527435, compound

Product 1

HCID 178527375HCID 178527375, compound

Procedure

The title compound was synthesized using Intermediate 15 and 1H-imidazole-4-sulfonyl chloride in a similar manner as described in Example 39. 1H NMR (DMSO-d6): δ 12.89 (1H, bs), 10.07 (1H, s), 8.41 (1H, d), 7.99 (1H, d), 7.92 (1H, s), 7.86 (2H, m), 7.79, (1H, dd), 5.32 (2H, s), 4.59 (1H, m), 3.62 (2H, m), 2.77 (2H, m), 2.17 (2H, m), 1.95 (2H, M).

Sources & evidence

ORD record
ord-f79572e4eda7464fb9c0e26ab76643df
Source dataset
uspto-grants-2014_09
Patent number
US08846675B2

Reaction notes

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