HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropanesulfonyl chloride → 5-((2-(1-(Cyclopropylsulfonyl)piperidin-4-yl)-2H-1,2,3-triazol-4-yl)methoxy)-2-(1H-tetrazol-1-yl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropanesulfonyl chloride | HCID 2760919 | — |
| Reactant | 5-((2-(piperidin-4-yl)-2H-1,2,3-triazol-4-yl)methoxy)-2-(1H-tetrazol-1-yl)pyridine hydrochloride | HCID 68746624 | — |
| Product | 5-((2-(1-(Cyclopropylsulfonyl)piperidin-4-yl)-2H-1,2,3-triazol-4-yl)methoxy)-2-(1H-tetrazol-1-yl)pyridine | HCID 25174271 | — |
Reaction Steps
The title compound was synthesized using Intermediate 15 and cyclopropanesulfonyl chloride in a similar manner as described in Example 39. 1H NMR (DMSO-d6): δ 9.45 (1H, s), 8.28 (1H, d), 8.03 (1H, d), 7.73 (1H, s), 7.58 (1H, dd), 5.28 (2H, s), 4.62 (1H, m), 3.87 (2H, m), 3.12 (2H, m) 2.31 (5H, m), 1.86 (2H, m), 1.02 (2H, m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846675B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-217521ea7aa848df83f85fc6cce8dfc6 |
| Source note | uspto-grants-2014_09 |