HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 1-benzyl-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Ethyl 2-acetylacetoacetate | HCID 79063 | — |
| Reactant | Benzylhydrazine dihydrochloride | HCID 146540 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-benzyl-3,5-dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester | HCID 9943096 | — |
Reaction Steps
Similar to Example 1, equimolar amounts of benzylhydrazine dihydrochloride and 2-acetyl-3-oxo-butyric acid ethyl ester were combined in a solution of 50% pyridine in ethanol. The resulting oil was determined to be the named product by 1H-NMR (CDCl3, ppm): 1.35 t (3H); 2.44 s (3H); 2.45 s (3H); 4.38 a (2H); 5.25 s (2H); 7.08 d (2H); 7.29 m (3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07087634B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-cdce1d85350340c0aefc14ad614d2d49 |
| Source note | uspto-grants-2006_08 |