HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-2-iodopyrimidine → 5-Chloro-2-(4-(4-((2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidin-1-yl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-2-iodopyrimidine | HCID 53949860 | — |
| Reactant | 4-(4-((2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidine hydrochloride | HCID 68746611 | — |
| Product | 5-Chloro-2-(4-(4-((2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidin-1-yl)pyrimidine | HCID 25175087 | — |
Reaction Steps
The title compound was synthesized from 4-(4-((2-fluoro-4-(1H-tetrazol-1-yl)phenoxy)methyl)-2H-1,2,3-triazol-2-yl)-2-methylpiperidine hydrochloride and 6-chloro-2-iodopyrimidine in a manner similar to that described in Example 9. The title compound was isolated as a mixture of four stereoisomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846675B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-5d23eac4af4e407bb1a16b7b24a66d8e |
| Source note | uspto-grants-2014_09 |