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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 80682Generated: October 27, 2026

8-Azabicyclo(3.2.1)octan-3-one → 8-(5-(Trifluoromethyl)pyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-3-one

https://huagongshe.com/reaction/80682

Reaction equation

Participants

RoleNameHCIDCharge
Reactant8-Azabicyclo(3.2.1)octan-3-oneHCID 434453—
Reactant2-(Methylsulfonyl)-5-(trifluoromethyl)pyrimidineHCID 21983749—
Product8-(5-(Trifluoromethyl)pyrimidin-2-yl)-8-azabicyclo[3.2.1]octan-3-oneHCID 57708423—

Reaction Steps

The title compound was synthesized from 2-(methylsulfonyl)-5-(trifluoromethyl)pyrimidine and 8-azabicyclo[3.2.1]octan-3-one in a manner similar to that described in Example 9.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08846675B2
Source datasetuspto-grants-2014_09
ORD IDord-2c8b74ede8d94be09fa82db0e5d59d0a
Source noteuspto-grants-2014_09