Ammonia → (4-Amino-2-chloro-pyrimidin-5-yl)-[3-(tert-butyl-dimethyl-silanyloxy)-5,6-difluoro-2-methoxy-phenyl]-methanone

HRID 806827Notes

Reaction equation

HRID 806827 reaction equation
[C:2]([CH3:3])([CH3:4])([CH3:5])[Si:6]([O:7][c:8]1[c:9]([O:26][CH3:27])[c:10]([C:16](=[O:17])[c:18]2[c:19]([Cl:25])[n:20][c:21]([Cl:24])[n:22][cH:23]2)[c:11]([F:15])[c:12]([F:14])[cH:13]1)([CH3:28])[CH3:29].[CH3:30][c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1.[NH3:1]>>[NH2:1][c:19]1[c:18]([C:16]([c:10]2[c:9]([O:26][CH3:27])[c:8]([O:7][Si:6]([C:2]([CH3:3])([CH3:4])[CH3:5])([CH3:28])[CH3:29])[cH:13][c:12]([F:14])[c:11]2[F:15])=[O:17])[cH:23][n:22][c:21]([Cl:24])[n:20]1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 1140TolueneHCID 21070521HCID 21070521, compound

Product 1

HCID 21070551(4-Amino-2-chloro-pyrimidin-5-yl)-[3-(tert-butyl-dimethyl-silanyloxy)-5,6-difluoro-2-methoxy-phenyl]-methanone

Sources & evidence

ORD record
ord-c12382ecfc2b44198de8bc55c37da2e5
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…