HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1-Dimethylethyl 4-hydroxy-3-methyl-1-piperidinecarboxylate → tert-Butyl 4-(4-((6-(1H-tetrazol-1-yl)pyridin-3-yloxy)methyl)-2H-1,2,3-triazol-2-yl)-3-methylpiperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1-Dimethylethyl 4-hydroxy-3-methyl-1-piperidinecarboxylate | HCID 51358491 | — |
| Reactant | 5-((2H-1,2,3-Triazol-4-yl)methoxy)-2-(1H-tetrazol-1-yl)pyridine | HCID 57708382 | — |
| Product | tert-Butyl 4-(4-((6-(1H-tetrazol-1-yl)pyridin-3-yloxy)methyl)-2H-1,2,3-triazol-2-yl)-3-methylpiperidine-1-carboxylate | HCID 25175579 | — |
Reaction Steps
The title compound was synthesized from Intermediate 13 and tert-butyl 4-hydroxy-3-methylpiperidine-1-carboxylate in a manner similar to that described in Example 69. The compounds were isolated as a mixture of four stereoisomers. Characterized by LCMS (ES+-MS found: 464 (M+Na), 442 (M+H)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846675B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-c89a623eeebe405aa41d481452817ad9 |
| Source note | uspto-grants-2014_09 |