Benzyl Alcohol → HCID 25175896, compound

HRID 80684Notes

Reaction equation

HRID 80684 reaction equation
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[N:5][C:6]([N:9]2[CH2:14][CH2:13][CH:12]([N:15]3[N:19]=[C:18]([CH2:20][OH:21])[CH:17]=[N:16]3)[CH2:11][CH2:10]2)=[N:7][CH:8]=1.[CH2:24](O)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[CH2:24]([O:21][CH2:20][C:18]1[CH:17]=[N:16][N:15]([CH:12]2[CH2:13][CH2:14][N:9]([C:6]3[N:5]=[CH:4][C:3]([C:2]([F:1])([F:22])[F:23])=[CH:8][N:7]=3)[CH2:10][CH2:11]2)[N:19]=1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 244Benzyl AlcoholHCID 57708393HCID 57708393, compound2×

Product 1

HCID 25175896HCID 25175896, compound

Procedure

The title compound was synthesized from (2-(1-(5-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-yl)-2H-1,2,3-triazol-4-yl)methanol (Intermediate 27) and benzyl alcohol in a manner similar to that described in Example 29. 1H NMR (CDCl3): δ 8.50 (2H, s), 7.60 (1H, s), 7.36-7.30 (5H, m), 4.86-4.82 (2H, m), 4.79-4.72 (1H, m), 4.62 (2H, s), 4.59 (2H, s), 3.33-3.26 (2H, m), 2.30-2.16 (4H, m).

Sources & evidence

ORD record
ord-81012f33de3246ee8896c77b720ff7ec
Source dataset
uspto-grants-2014_09
Patent number
US08846675B2

Reaction notes

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