Ethanol → 2,6-dichloro-5-fluoro-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine

HRID 806894Notes

Reaction equation

HRID 806894 reaction equation
[CH3:11][c:12]1[cH:13][c:14]([NH2:17])[n:15][nH:16]1.[CH3:18][CH2:19][OH:20].[Cl:1][c:2]1[n:3][c:4]([Cl:10])[c:5]([F:9])[c:6]([Cl:8])[n:7]1>>[Cl:1][c:2]1[n:3][c:4]([NH:17][c:14]2[cH:13][c:12]([CH3:11])[nH:16][n:15]2)[c:5]([F:9])[c:6]([Cl:8])[n:7]1

Participants

4

Reactant 3

HCID 702EthanolHCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 133889932,4,6-Trichloro-5-fluoropyrimidine

Product 1

HCID 509937272,6-dichloro-5-fluoro-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine

Sources & evidence

ORD record
ord-0566a5c2c3f146f99fdbe120ac6521ec
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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