3-Pyridinemethanamine → 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-(pyridin-3-ylmethyl)-4-(trifluoromethyl)thiazole-5-carboxamide

HRID 807115Notes

Reaction equation

HRID 807115 reaction equation
[CH:1]1([CH2:2][N:3]2[CH2:4][CH2:5][N:6]([c:7]3[s:8][c:9]([C:10]([OH:11])=[O:12])[cH:13][n:14]3)[C:15]2=[O:16])[CH2:17][CH2:18]1.[F:19][c:20]1[cH:21][cH:22][c:23]([CH2:24][N:25]2[C:26](=[O:42])[N:27]([c:30]3[s:31][c:32]([C:39](=[O:40])[OH:41])[c:33]([C:35]([F:36])([F:37])[F:38])[n:34]3)[CH2:28][CH2:29]2)[cH:43][cH:44]1.[n:45]1[cH:46][c:47]([CH2:51][NH2:52])[cH:48][cH:49][cH:50]1>>[F:19][c:20]1[cH:21][cH:22][c:23]([CH2:24][N:25]2[C:26](=[O:42])[N:27]([c:30]3[s:31][c:32]([C:39](=[O:41])[NH:52][CH2:51][c:47]4[cH:46][n:45][cH:50][cH:49][cH:48]4)[c:33]([C:35]([F:36])([F:37])[F:38])[n:34]3)[CH2:28][CH2:29]2)[cH:43][cH:44]1

Participants

4

Reactant 3

HCID 310183-PyridinemethanamineHCID 580314172-(3-(Cyclopropylmethyl)-2-oxoimidazolidin-1-yl)thiazole-5-carboxylic acidHCID 594812062-(3-(4-Fluorobenzyl)-2-oxoimidazolidin-1-yl)-4-(trifluoromethyl)thiazole-5-carboxylic acid

Product 1

HCID 594812792-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-N-(pyridin-3-ylmethyl)-4-(trifluoromethyl)thiazole-5-carboxamide

Sources & evidence

ORD record
ord-5cfbca75cea9499799fa289b4f4c1ef3
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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