HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Dimethylaminopyridine → HCID 59406959, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Dimethylaminopyridine | HCID 21885 | — |
| Reactant | Carbonic acid, bis(1,1-dimethylethyl) ester | HCID 10219638 | — |
| Reactant | 2-(4-Fluorophenyl)-3-iodo-7,8-dimethyl-6-piperazin-1-ylimidazo[1,2-b]pyridazine | HCID 59406963 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 59406959 | HCID 59406959 | 78.4% |
Reaction Steps
A solution of 0.70 g (1.55 mmol) of 2-(4-fluorophenyl)-3-iodo-7,8-dimethyl-6-piperazin-1-ylimidazo[1,2-b]pyridazine and 19 mg (0.16 mmol) of dimethylaminopyridine in 10 mL of tetrahydrofuran is treated with 0.41 g (1.9 mmol) of di-tert-butyl carbonate for 1 hour. The solvent is then evaporated off and the solid obtained is recrystallized from acetonitrile. 0.67 g of product is thus isolated after drying.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08846676B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-9116dc6336ab4c4e9bb40f58c13e565f |
| Source note | uspto-grants-2014_09 |