反应详情

温度

150 °C

0.10 g (0.25 mmol) of 2-(4-fluorophenyl)-3-(2-fluoropyrid-4-yl)-6-(4-methylpiperazin-1-yl)imidazo[1,2-b]pyridazine and 10 mL of dimethylamine are introduced into an autoclave. The mixture is heated at 150° C. overnight and then cooled and poured into water. The product is extracted with chloroform, and the organic phase is dried over sodium sulfate and then concentrated under reduced pressure to give a solid. This solid is crystallized and recrystallized from acetonitrile to give 0.028 g of a white powder after cooling, filtering off and drying.

1. temperaturecooled
2. extractionThe product is extracted with chloroform
3. dry with materialthe organic phase is dried over sodium sulfate
4. concentrationconcentrated under reduced pressure
5. customto give a solid
6. customThis solid is crystallized
7. customrecrystallized from acetonitrile