N-Iodosuccinimide → Tert-butyl 4-[2-(4-fluorophenyl)-3-iodoimidazo[1,2-b]pyridazin-6-yl]piperazine-1-carboxylate

Participants

Reaction Steps

To a solution of 28.0 g (70.5 mmol) of tert-butyl 4-[2-(4-fluorophenyl)imidazo[1,2-b]pyridazin-6-yl]piperazine-1-carboxylate in 800 mL of tetrahydrofuran cooled to about 0° C. are added 17.4 g (77.5 mmol) of N-iodosuccinimide. After stirring for 18 hours at room temperature, the solvent is evaporated off under reduced pressure.

Provenance & Evidence