2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-hydroxy-1-morpholin-4-ylpropyl)pyridin-2-yl]amino}thiophene-3-carboxamide
Reaction equation
[Br:21][c:22]1[cH:23][cH:24][cH:25][c:26]([CH:28]([CH:29]([CH3:30])[OH:31])[N:32]2[CH2:33][CH2:34][O:35][CH2:36][CH2:37]2)[n:27]1.[NH2:1][c:2]1[s:3][c:4](-[c:10]2[c:11]([F:20])[cH:12][c:13]([C:16]([CH3:17])([CH3:18])[OH:19])[cH:14][cH:15]2)[cH:5][c:6]1[C:7](=[O:8])[NH2:9]>>[NH:1]([c:2]1[s:3][c:4](-[c:10]2[c:11]([F:20])[cH:12][c:13]([C:16]([CH3:17])([CH3:18])[OH:19])[cH:14][cH:15]2)[cH:5][c:6]1[C:7](=[O:8])[NH2:9])[c:22]1[cH:23][cH:24][cH:25][c:26]([CH:28]([CH:29]([CH3:30])[OH:31])[N:32]2[CH2:33][CH2:34][O:35][CH2:36][CH2:37]2)[n:27]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-7df61db42e314d7391cb48649e81df4a
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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