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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 807349Generated: October 25, 2026

Hydrochloric Acid → 5-(3,3-Difluoroazetidin-1-yl)-6-(2-methoxyethoxy)-pyridine-2-carboxylic acid methyl ester

https://huagongshe.com/reaction/807349

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantTolueneHCID 1140—
ReactantCarbonate IonHCID 19660—
ReactantPalladiumHCID 23938—
ReactantDibenzylidene acetoneHCID 95417—
ReactantCesium cationHCID 104967—
Reactant3,3-DifluoroazetidineHCID 2758248—
Reactant5-Bromo-6-(2-methoxyethoxy)-pyridine-2-carboxylic acid methyl esterHCID 71087799—
Product5-(3,3-Difluoroazetidin-1-yl)-6-(2-methoxyethoxy)-pyridine-2-carboxylic acid methyl esterHCID 71087451—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTest data from https://doi.org/10.1039/C8SC04228D
ORD IDord-f2eaba357b734516a9da17137aa04092
Source noteTest data from https://doi.org/10.1039/C8SC04228D