Methanol → 5-Fluoro-4-[4-(1-methylethyl)-1-piperazinyl]-2-(methyloxy)aniline

HRID 807573Notes

Reaction equation

HRID 807573 reaction equation
[CH3:25][OH:26].[Cl:27][Fe:28]([Cl:29])[Cl:30].[F:1][c:2]1[c:3]([N:13]2[CH2:14][CH2:15][N:16]([CH:19]([CH3:20])[CH3:21])[CH2:17][CH2:18]2)[cH:4][c:5]([O:11][CH3:12])[c:6]([N+:8]([O-:9])=[O:10])[cH:7]1.[NH2:23][NH2:24].[OH2:22]>>[F:1][c:2]1[c:3]([N:13]2[CH2:14][CH2:15][N:16]([CH:19]([CH3:20])[CH3:21])[CH2:17][CH2:18]2)[cH:4][c:5]([O:11][CH3:12])[c:6]([NH2:8])[cH:7]1

Participants

6

Reactant 5

HCID 887MethanolHCID 962WaterHCID 9321HydrazineHCID 24380Iron chloride (FeCl3)HCID 594420111-[2-Fluoro-5-(methyloxy)-4-nitrophenyl]-4-(1-methylethyl)piperazine

Product 1

HCID 594418305-Fluoro-4-[4-(1-methylethyl)-1-piperazinyl]-2-(methyloxy)aniline

Sources & evidence

ORD record
ord-182fdf9c136c4183909e88a19df3fc64
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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