Dimethyl Sulfoxide → Tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate

HRID 807620Notes

Reaction equation

HRID 807620 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([N+:8](=[O:9])[O-:10])[n:6][cH:7]1.[C:42](=[O:43])([O-:44])[O-:45].[CH2:25]([N+:26]([CH2:27][CH2:28][CH2:29][CH3:30])([CH2:31][CH2:32][CH2:33][CH3:34])[CH2:35][CH2:36][CH2:37][CH3:38])[CH2:39][CH2:40][CH3:41].[CH3:48][S:49]([CH3:50])=[O:51].[I+:24].[K+:46].[K+:47].[N:11]1([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]1>>[c:2]1([N:14]2[CH2:13][CH2:12][N:11]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:16][CH2:15]2)[cH:3][cH:4][c:5]([N+:8](=[O:9])[O-:10])[n:6][cH:7]1

Participants

8

Reactant 7

HCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 16028TetrabutylammoniumHCID 19660Carbonate IonHCID 143452tert-Butyl piperazine-1-carboxylateHCID 8176205-Bromo-2-nitropyridineHCID 5460719Iodine(1+)

Product 1

HCID 11243758Tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-5f3d1d0035f342e3bdf6bc28afbf5b1a
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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