Pyridine → propan-2-yl 4-acetamido-2-cyclopropyl-6-(trifluoromethyl)-3,4-dihydro-2H-1,5-naphthyridine-1-carboxylate

HRID 807680Notes

Reaction equation

HRID 807680 reaction equation
[CH3:1][O:2][c:3]1[n:4][c:5]2[c:6]([cH:7][cH:8]1)[NH:9][CH:10]([CH3:11])[CH2:12][CH:13]2[NH:14][C:15](=[O:16])[CH3:17].[CH3:46][N:47]([c:48]1[cH:49][cH:50][cH:51][cH:52][n:53]1)[CH3:54].[CH:18]1([CH:21]2[NH:22][c:23]3[cH:24][cH:25][c:26]([C:35]([F:36])([F:37])[F:38])[n:27][c:28]3[CH:29]([NH:31][C:32]([CH3:33])=[O:34])[CH2:30]2)[CH2:19][CH2:20]1.[Cl:39][C:40](=[O:41])[O:42][CH:43]([CH3:44])[CH3:45].[cH:55]1[cH:56][cH:57][n:58][cH:59][cH:60]1>>[CH:18]1([CH:21]2[N:22]([C:40](=[O:41])[O:42][CH:43]([CH3:44])[CH3:45])[c:23]3[cH:24][cH:25][c:26]([C:35]([F:36])([F:37])[F:38])[n:27][c:28]3[CH:29]([NH:31][C:32]([CH3:33])=[O:34])[CH2:30]2)[CH2:19][CH2:20]1

Participants

6

Reactant 5

HCID 1049PyridineHCID 7917Isopropyl chloroformateHCID 218852-DimethylaminopyridineHCID 58926725N-[2-cyclopropyl-6-(trifluoromethyl)-1,2,3,4-tetrahydro-1,5-naphthyridin-4-yl]acetamideHCID 58926730N-(6-methoxy-2-methyl-1,2,3,4-tetrahydro-1,5-naphthyridin-4-yl)acetamide

Product 1

HCID 58926724propan-2-yl 4-acetamido-2-cyclopropyl-6-(trifluoromethyl)-3,4-dihydro-2H-1,5-naphthyridine-1-carboxylate

Sources & evidence

ORD record
ord-2805a375842e4472954c481a3b6159d2
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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