1-[2-(4-Aminopiperidin-1-yl)ethyl]-2-oxo-1,2-dihydroquinoline-7-carbonitrile → 4-[2-(4-Aminopiperidin-1-yl)ethyl]-6-fluoro-2H-1,4-benzoxazin-3(4H)-one

HRID 808035Notes

Reaction equation

HRID 808035 reaction equation
[F:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:28]1)[N:7]([CH2:12][CH2:13][N:14]1[CH2:15][CH2:16][CH:17]([NH:20][C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:18][CH2:19]1)[C:8](=[O:11])[CH2:9][O:10]2.[NH2:29][CH:30]1[CH2:31][CH2:32][N:33]([CH2:34][CH2:35][n:36]2[c:37]3[c:38]([cH:39][cH:40][c:41]([C:42]#[N:43])[cH:44]3)[cH:45][cH:46][c:47]2=[O:48])[CH2:49][CH2:50]1>>[F:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:28]1)[N:7]([CH2:12][CH2:13][N:14]1[CH2:15][CH2:16][CH:17]([NH2:20])[CH2:18][CH2:19]1)[C:8](=[O:11])[CH2:9][O:10]2

Participants

3

Reactant 2

HCID 602009201-[2-(4-Aminopiperidin-1-yl)ethyl]-2-oxo-1,2-dihydroquinoline-7-carbonitrileHCID 86642612tert-Butyl {1-[2-(6-fluoro-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)ethyl]piperidin-4-yl}carbamate

Product 1

HCID 667743534-[2-(4-Aminopiperidin-1-yl)ethyl]-6-fluoro-2H-1,4-benzoxazin-3(4H)-one

Sources & evidence

ORD record
ord-b2c463fff0fb4a12ad1a2e36ff9ad723
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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