2-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({5-[3-(2-hydroxyethyl)-1,2,4-oxadiazol-5-yl]-6-methylpyridin-2-yl}amino)thiophene-3-carboxamide

HRID 808214Notes

Reaction equation

HRID 808214 reaction equation
[Cl:22][c:23]1[cH:24][cH:25][c:26](-[c:30]2[n:31][c:32]([CH2:35][CH2:36][OH:37])[n:33][o:34]2)[c:27]([CH3:29])[n:28]1.[NH2:1][c:2]1[s:3][c:4](-[c:10]2[c:11]([F:21])[cH:12][c:13]([C:17]([CH3:18])([CH3:19])[OH:20])[cH:14][c:15]2[F:16])[cH:5][c:6]1[C:7](=[O:8])[NH2:9]>>[NH:1]([c:2]1[s:3][c:4](-[c:10]2[c:11]([F:21])[cH:12][c:13]([C:17]([CH3:18])([CH3:19])[OH:20])[cH:14][c:15]2[F:16])[cH:5][c:6]1[C:7](=[O:8])[NH2:9])[c:23]1[cH:24][cH:25][c:26](-[c:30]2[n:31][c:32]([CH2:35][CH2:36][OH:37])[n:33][o:34]2)[c:27]([CH3:29])[n:28]1

Participants

3

Reactant 2

HCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595258502-[5-(6-Chloro-2-methylpyridin-3-yl)-1,2,4-oxadiazol-3-yl]ethanol

Product 1

HCID 595260755-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({5-[3-(2-hydroxyethyl)-1,2,4-oxadiazol-5-yl]-6-methylpyridin-2-yl}amino)thiophene-3-carboxamide

Sources & evidence

ORD record
ord-55feaf9d786f4a19804f322de34a91ad
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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