Pyridine → Methanesulfonic acid 2-(4-{2-[2-(3,5-difluoro-phenyl)-acetylamino]-pentanoylamino}-imidazol-1-yl)-ethyl ester

HRID 808446Notes

Reaction equation

HRID 808446 reaction equation
[CH3:28][S:29](=[O:30])(=[O:31])[Cl:32].[OH:1][CH2:2][CH2:3][n:4]1[cH:5][n:6][c:7]([NH:9][C:10]([CH:11]([CH2:12][CH2:13][CH3:14])[NH:15][C:16]([CH2:17][c:18]2[cH:19][c:20]([F:25])[cH:21][c:22]([F:24])[cH:23]2)=[O:26])=[O:27])[cH:8]1.[cH:33]1[cH:34][cH:35][n:36][cH:37][cH:38]1>>[O:1]([CH2:2][CH2:3][n:4]1[cH:5][n:6][c:7]([NH:9][C:10]([CH:11]([CH2:12][CH2:13][CH3:14])[NH:15][C:16]([CH2:17][c:18]2[cH:19][c:20]([F:25])[cH:21][c:22]([F:24])[cH:23]2)=[O:26])=[O:27])[cH:8]1)[S:29]([CH3:28])(=[O:30])=[O:31]

Participants

4

Reactant 3

HCID 1049PyridineHCID 31297Methanesulfonyl chlorideHCID 115960342-[2-(3,5-Difluoro-phenyl)-acetylamino]-pentanoic acid [1-(2-hydroxy-ethyl)-1H-imidazol-4-yl]-amide

Product 1

HCID 86600814Methanesulfonic acid 2-(4-{2-[2-(3,5-difluoro-phenyl)-acetylamino]-pentanoylamino}-imidazol-1-yl)-ethyl ester

Sources & evidence

ORD record
ord-cb21e08134fc46bea7f57081bcc47b82
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…