Dichloromethane → [2-(3-Bromo-phenyl)-2-tert-butoxycarbonylamino-3,3,3-trifluoro-propoxy]-acetic acid ethyl ester

HRID 808543Notes

Reaction equation

HRID 808543 reaction equation
[C:9]([CH3:10])([CH3:11])([CH3:12])[O:13][C:14]([NH:15][C:16]([C:17]([F:18])([F:19])[F:20])([CH2:21][OH:22])[c:23]1[cH:24][c:25]([Br:29])[cH:26][cH:27][cH:28]1)=[O:30].[Cl:31][CH2:32][Cl:33].[N+:1](=[N-:2])=[CH:3][C:4](=[O:5])[O:6][CH2:7][CH3:8]>>[CH2:3]([C:4](=[O:5])[O:6][CH2:7][CH3:8])[O:22][CH2:21][C:16]([NH:15][C:14]([O:13][C:9]([CH3:10])([CH3:11])[CH3:12])=[O:30])([C:17]([F:18])([F:19])[F:20])[c:23]1[cH:24][c:25]([Br:29])[cH:26][cH:27][cH:28]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 12192Ethyl diazoacetateHCID 66665702[1-(3-Bromo-phenyl)-2,2,2-trifluoro-1-hydroxymethyl-ethyl]-carbamic acid tert-butyl ester

Product 1

HCID 66666311[2-(3-Bromo-phenyl)-2-tert-butoxycarbonylamino-3,3,3-trifluoro-propoxy]-acetic acid ethyl ester

Sources & evidence

ORD record
ord-9c0f85849e684c7cbac55dd7da948712
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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