7-bromo-5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-1,6-naphthyridin-2(1H)-one → 7-[(1-tert-butylpiperidin-4-ylidene)methyl]-5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-1,6-naphthyridin-2(1H)-one

HRID 808547Notes

Reaction equation

HRID 808547 reaction equation
[Br:1][c:2]1[n:3][c:4](-[c:21]2[c:22]([Cl:28])[cH:23][c:24]([F:27])[cH:25][cH:26]2)[c:5]2[cH:6][cH:7][c:8](=[O:20])[n:9](-[c:12]3[c:13]([Cl:19])[cH:14][cH:15][cH:16][c:17]3[Cl:18])[c:10]2[cH:11]1.[C:29]([CH3:30])([CH3:31])([CH3:32])[N:33]1[CH2:34][CH2:35][C:36](=[CH:39][Sn:40]([CH3:41])([CH3:42])[CH3:43])[CH2:37][CH2:38]1>>[c:2]1([CH:39]=[C:36]2[CH2:35][CH2:34][N:33]([C:29]([CH3:30])([CH3:31])[CH3:32])[CH2:38][CH2:37]2)[n:3][c:4](-[c:21]2[c:22]([Cl:28])[cH:23][c:24]([F:27])[cH:25][cH:26]2)[c:5]2[cH:6][cH:7][c:8](=[O:20])[n:9](-[c:12]3[c:13]([Cl:19])[cH:14][cH:15][cH:16][c:17]3[Cl:18])[c:10]2[cH:11]1

Participants

3

Reactant 2

HCID 226479107-bromo-5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-1,6-naphthyridin-2(1H)-oneHCID 226479361-Tert-butyl-4-[(trimethylstannyl)methylene]piperidine

Product 1

HCID 226481727-[(1-tert-butylpiperidin-4-ylidene)methyl]-5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-1,6-naphthyridin-2(1H)-one

Sources & evidence

ORD record
ord-c7378d40d8d948a0b6ba50f88072c696
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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