1-Boc-2-(3-amino-5-trifluoromethyl-phenoxymethyl)-pyrrolidine → 1-Boc-2-[3-[(2-Fluoro-pyridine-3-carbonyl)-amino]-5-trifluoromethyl-phenoxymethyl}-pyrrolidine
Reaction equation
[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH:9]([CH2:13][O:14][c:15]2[cH:16][c:17]([NH2:25])[cH:18][c:19]([C:21]([F:22])([F:23])[F:24])[cH:20]2)[CH2:10][CH2:11][CH2:12]1.[C:26]([N:27]1[CH2:28][CH2:29][CH:30]([O:31][c:32]2[cH:33][c:34]([C:35]([F:36])([F:37])[F:38])[cH:39][c:40]([NH:41][C:51](=[O:52])[c:53]3[c:54]([F:59])[n:55][cH:56][cH:57][cH:58]3)[cH:42]2)[CH2:43][CH2:44]1)([O:45][C:46]([CH3:47])([CH3:48])[CH3:49])=[O:50]>>[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH:9]([CH2:13][O:14][c:15]2[cH:16][c:17]([NH:25][C:51](=[O:52])[c:53]3[c:54]([F:59])[n:55][cH:56][cH:57][cH:58]3)[cH:18][c:19]([C:21]([F:22])([F:23])[F:24])[cH:20]2)[CH2:10][CH2:11][CH2:12]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-887b3050e10e48acaffbc9d3b1d6463a
- Source dataset
- Test data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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