反应详情

温度

100 °C

A mixture of 2-chloro-5-(4-chlorophenyl)pyridine (500 mg, 2.23 mmol), DMSO (2.0 mL) and 1-isopropylpiperazine (3 mL, 23.4 mmol) was stirred and heated on a 100° C. oil-bath overnight. The reaction mixture was poured into water (75 mL), and the solid was isolated by filtration, washed with water and dried. The crude product was purified by column chromatography on silica gel (Kiselgel 60, mesh 0.040-0.63) eluting with a mixture of ethyl acetate and methanol (4:1). Collecting the proper fractions afforded 600 mg (85%) of 1-[5-(4-chlorophenyl)pyridin-2-yl]-4-isopropylpiperazine.

1. customthe solid was isolated by filtration
2. washwashed with water
3. customdried
4. customThe crude product was purified by column chromatography on silica gel (Kiselgel 60, mesh 0.040-0.63)
5. washeluting with a mixture of ethyl acetate and methanol (4:1)
6. customCollecting the proper fractions