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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 80881Generated: October 26, 2026

1-[(1-Methylpiperidin-3-yl)methyl]piperazine → 3-[4-(1-Methylpiperidin-3-ylmethyl)piperazin-1-yl]-6-(4-trifluoromethylphenyl)pyridazine

https://huagongshe.com/reaction/80881

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-[(1-Methylpiperidin-3-yl)methyl]piperazineHCID 2736940—
ReactantPyridazine, 3-chloro-6-[4-(trifluoromethyl)phenyl]-HCID 12449554—
Product3-[4-(1-Methylpiperidin-3-ylmethyl)piperazin-1-yl]-6-(4-trifluoromethylphenyl)pyridazineHCID 15951317—

Reaction Steps

The title compound was prepared by a similar procedure to that described in Example 1, starting from 3-chloro-6-(4-trifluoromethylphenyl)pyridazine and (1-methylpiperidin-3-ylmethyl)piperazine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08846677B2
Source datasetuspto-grants-2014_09
ORD IDord-fa2c8ae6bd9046c998b5515af50314ae
Source noteuspto-grants-2014_09