1-Isopropylpiperazine → 5-(4-Chlorophenyl)-2-(4-isopropylpiperazin-1-yl)-pyrimidine dihydrochloride

HRID 80885Notes

Reaction equation

HRID 80885 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)=[CH:4][N:3]=1.[CH:15]([N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1)([CH3:17])[CH3:16]>>[ClH:1].[ClH:1].[Cl:14][C:11]1[CH:12]=[CH:13][C:8]([C:5]2[CH:4]=[N:3][C:2]([N:21]3[CH2:22][CH2:23][N:18]([CH:15]([CH3:17])[CH3:16])[CH2:19][CH2:20]3)=[N:7][CH:6]=2)=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 780131-IsopropylpiperazineHCID 27610252-Chloro-5-(4-chlorophenyl)pyrimidine

Product 1

HCID 1317307685-(4-Chlorophenyl)-2-(4-isopropylpiperazin-1-yl)-pyrimidine dihydrochloride

Procedure

The title compound was prepared by a similar procedure to that described in Example 1, starting from 2-chloro-5-(4-chlorophenyl)pyrimidine and 1-isopropylpiperazine.

Sources & evidence

ORD record
ord-25ad0698c7ee40bf80042f09a358993a
Source dataset
uspto-grants-2014_09
Patent number
US08846677B2

Reaction notes

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