1-Isopropylpiperazine → HCID 131730769, compound

HRID 80886Notes

Reaction equation

[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)=[CH:4][N:3]=1.[CH:18]([N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)([CH3:20])[CH3:19]>>[ClH:1].[CH:18]([N:21]1[CH2:26][CH2:25][N:24]([C:2]2[N:7]=[CH:6][C:5]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=3)=[CH:4][N:3]=2)[CH2:23][CH2:22]1)([CH3:20])[CH3:19]

Participants

Reactant 2

HCID 780131-Isopropylpiperazine

HCID 203333442-Chloro-5-[4-(trifluoromethyl)phenyl]pyrimidine

Product 1

HCID 131730769HCID 131730769, compound

Procedure

The title compound was prepared by a similar procedure to that described in Example 1, starting from 2-chloro-5-(4-trifluoromethylphenyl)pyrimidine and 1-isopropylpiperazine.

Sources & evidence

ORD record: ord-706f0a373cae4e21a24759aec63c0237
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08846677B2

Reaction notes

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