Methanol → 5-[3-(4-Fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-pyridine-2-carboxylic acid ethyl ester

HRID 808869Notes

Reaction equation

HRID 808869 reaction equation
[BH4-:34].[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[n:7][cH:8][c:9]([O:12][CH2:13][c:14]2[c:15](-[c:27]3[cH:28][cH:29][c:30]([F:33])[cH:31][cH:32]3)[n:16][o:17][c:18]2[CH:19]=[CH:20][c:21]2[cH:22][cH:23][cH:24][cH:25][cH:26]2)[cH:10][cH:11]1.[CH3:36][OH:37].[Na+:35]>>[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[n:7][cH:8][c:9]([O:12][CH2:13][c:14]2[c:15](-[c:27]3[cH:28][cH:29][c:30]([F:33])[cH:31][cH:32]3)[n:16][o:17][c:18]2[CH2:19][OH:37])[cH:10][cH:11]1

Participants

5

Reactant 4

HCID 887MethanolHCID 923Sodium ionHCID 28123BorohydrideHCID 66644440Ethyl 5-[[3-(4-fluorophenyl)-5-(2-phenylethenyl)-1,2-oxazol-4-yl]methoxy]pyridine-2-carboxylate

Product 1

HCID 666445155-[3-(4-Fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-pyridine-2-carboxylic acid ethyl ester

Sources & evidence

ORD record
ord-2c569e4d8bf5421b92dee357f0cce33a
Source dataset
Test data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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