1-Isopropylpiperazine → 4-(2-(4-Isopropylpiperazin-1-yl)-pyrimidin-5-yl)-benzonitrile dihydrochloride

HRID 80887Notes

Reaction equation

[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]#[N:15])=[CH:10][CH:9]=2)=[CH:4][N:3]=1.[CH:16]([N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)([CH3:18])[CH3:17]>>[ClH:1].[ClH:1].[CH:16]([N:19]1[CH2:24][CH2:23][N:22]([C:2]2[N:7]=[CH:6][C:5]([C:8]3[CH:13]=[CH:12][C:11]([C:14]#[N:15])=[CH:10][CH:9]=3)=[CH:4][N:3]=2)[CH2:21][CH2:20]1)([CH3:18])[CH3:17]

Participants

Reactant 2

HCID 780131-Isopropylpiperazine

HCID 86637102HCID 86637102, compound

Product 1

HCID 1317307704-(2-(4-Isopropylpiperazin-1-yl)-pyrimidin-5-yl)-benzonitrile dihydrochloride

Procedure

The title compound was prepared by a similar procedure to that described in Example 1, starting from 2-chloro-5-(4-cyanophenyl)pyrimidine and 1-isopropylpiperazine.

Sources & evidence

ORD record: ord-987441edfe2e44d28981ee9fb51dd119
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08846677B2

Reaction notes

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