3-Chloro-6-(4-cyanophenyl)pyridazine → 4-(6-{[1-(Pentan-3-yl)piperidin-4-yl]amino}pyridazin-3-yl)benzonitrile

HRID 80892Notes

Reaction equation

HRID 80892 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]#[N:15])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1.[NH2:16][CH:17]1[CH2:22][CH2:21][N:20]([CH:23]([CH2:26][CH3:27])[CH2:24][CH3:25])[CH2:19][CH2:18]1>>[CH2:24]([CH:23]([N:20]1[CH2:21][CH2:22][CH:17]([NH:16][C:2]2[N:3]=[N:4][C:5]([C:8]3[CH:13]=[CH:12][C:11]([C:14]#[N:15])=[CH:10][CH:9]=3)=[CH:6][CH:7]=2)[CH2:18][CH2:19]1)[CH2:26][CH3:27])[CH3:25]

Participants

3

Reactant 2

HCID 64052563-Chloro-6-(4-cyanophenyl)pyridazineHCID 246980774-Amino-1-(1-ethylpropyl)piperidine

Product 1

HCID 159513834-(6-{[1-(Pentan-3-yl)piperidin-4-yl]amino}pyridazin-3-yl)benzonitrile

Procedure

The title compound was prepared by a similar procedure to that described in Example 1, starting from 3-chloro-6-(4-cyanophenyl)pyridazine and 4-amino-1-(1-ethylpropyl)piperidine.

Sources & evidence

ORD record
ord-6437de060f04496095ac6b7786f1a3f6
Source dataset
uspto-grants-2014_09
Patent number
US08846677B2

Reaction notes

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