2H-Pyran, 4-chlorotetrahydro- → 1-(Tetrahydropyran-4-yl)-4-[5-(4-trifluoromethylphenyl)pyridin-2-yl]piperazine

HRID 80894Notes

Reaction equation

HRID 80894 reaction equation
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[CH:11][C:12]([N:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)=[N:13][CH:14]=2)=[CH:5][CH:4]=1.Cl[CH:24]1[CH2:29][CH2:28][O:27][CH2:26][CH2:25]1>>[O:27]1[CH2:28][CH2:29][CH:24]([N:18]2[CH2:19][CH2:20][N:15]([C:12]3[CH:11]=[CH:10][C:9]([C:6]4[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:21])[F:22])=[CH:8][CH:7]=4)=[CH:14][N:13]=3)[CH2:16][CH2:17]2)[CH2:25][CH2:26]1

Participants

3

Reactant 2

HCID 1372022H-Pyran, 4-chlorotetrahydro-HCID 671450024-(5-(4-Trifluoromethylphenyl)pyridin-2-yl)piperazine

Product 1

HCID 159513851-(Tetrahydropyran-4-yl)-4-[5-(4-trifluoromethylphenyl)pyridin-2-yl]piperazine

Procedure

The title compound was prepared by a similar procedure to that described in Example 57, starting from 4-(5-(4-trifluoromethylphenyl)pyridin-2-yl)piperazine and 4-chloro-tetrahydropyran.

Sources & evidence

ORD record
ord-278c3a981e0845ac874b50506e7683e4
Source dataset
uspto-grants-2014_09
Patent number
US08846677B2

Reaction notes

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